clinical picture reactive-arthritis

Reactive arthritis

(Reiter's Syndrome or Reiter's arthritis), is classified as an autoimmune condition that develops in response to an infection in another part of the body. Coming into contact with bacteria and developing an infection can trigger the disease. It has symptoms similar to various other conditions collectively known as "arthritis". By the time the patient presents with symptoms, often time the "trigger" infection has been cured or is in remission in chronic cases, thus making determination of the initial cause difficult.

Reactive arthritis has also been known as Reiter's Syndrome, arthritis urethritica, venereal arthritis and polyarteritis enterica. It is a type of seronegative spondyloarthropathy. The original name "Reiter’s syndrome" , named after the German physician Hans Conrad Julius Reiter for his contributions to identification and description of the disease, has become unpopular in the past decade as Reiter's history of Nazi party membership, allegations of experimentation in the Buchenwald concentration camp, and prosecution in Nuremburg as a war criminal, have come to light.

The manifestations of Reactive arthritis include the following triad of symptoms: an inflammatory arthritis of large joints including commonly the knee and the back (due to involvement of the sacroiliac joint), inflammation of the eyes in the form of (conjunctivitis or uveitis), and urethritis in men or cervicitis in women. Patients can also present with mucocutaneous leisons, as well as psoriasis-like skin lesions such as circinate balanitis, and keratoderma blennorrhagica. Enthesitis can involve the Achilles tendon resulting in heel pain. Not all affected persons have all the manifestations, and the formal definition of the disease is the occurrence of otherwise unexplained non-infectious inflammatory arthritis combined with urethritis in men, or cervicitis in women.

Reactive arthritis is an RF-seronegative, HLA-B27-linked spondyloarthropathycartilages of joints) often precipitated by genitourinary or gastrointestinal infections. The most common triggers are sexually transmitted Chlamydial infections and perhaps, less commonly, Nisseria gonorrhea; and Salmonella, Shigella, or Campylobacter intestinal infections. (autoimmune damage to the

Reactive arthritis most commonly strikes individuals aged 20–40 year of age, and is more common in men than in women, and more common in whites than in blacks. This is owing to the high frequency the of HLA-27 gene in the white population. Patients with HIV have an increased risk of developing reactive arthritis as well.

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